468 0 obj endobj 390 0 obj Full text Full text is available as a scanned copy of the original print version. 211 0 obj -7.55399 0 Td e�);Nb|��y0���. (accessed free at)Tj <>/MediaBox[0 0 609.84 792.12]/Parent 534 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 21/Tabs/S/Type/Page>> 397 0 obj endobj endobj /T1_3 1 Tf 467 0 obj /T1_0 1 Tf DOI: 10.1074/jbc.M113.515890 Corpus ID: 10279237. 0 1.00001 TD endobj <> endobj 2 0 obj 0 g -19.67698 0 Td endobj <> 488 0 obj <> [291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R] 407 0 obj endobj 468 0 obj 0 1 TD /T1_0 1 Tf 89 468 m '����~���Z�`Ϩ��,��MSdF��$i��SI9�GM@\}/���coz�RjO]b�Đt�@a�[Um����P�O���O�:D��iH ����Lq�wI���b��AY��S+@`v#%@��q�� ��79R�!�5F��ȉgy�� �xȃI9^�H,�)8>/�%*K�=�Eq2�Y����d����Ve8�������^T��(�hŇ��\��/e���o��Zy. <> application/pdf 0 0 1 rg <> endobj ET /T1_3 1 Tf mRNA stability, translation, enzyme phosphorylation and enzyme degradation. S 460 0 obj BT [411 0 R 412 0 R 413 0 R 414 0 R 231 0 R] <> [259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R] 473 0 obj 471 0 obj endobj endobj <> T* [307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R] endobj ( )Tj Contain 24 carbon atoms, 2 or 3 OH groups in steroid nucleus & a side chain ending in carboxyl group. BT Free fulltext PDF articles from hundreds of disciplines, all in one place Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment (pdf) | Paperity Thisarticle mustthereforebeherebymarked"ad-vertisement"inaccordancewith 18U. Degradation of EGFR through APMAP Siyuan Jiang1, Xuetong Wang1, Dalong Song2, XiaoJun Liu1,Yinmin Gu1, ... High cholesterol inhibits EGFR internalization by promoting the competitive binding of APMAP to EPS15R, which in turn activates ERK1/2 to promote epithelial-to-mesenchymal transition. <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> Links to PubMed are also available for Selected References. <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> 503 0 obj endobj <> When cholesterol levels are low, Scap escorts SREBPs from the ER to the Golgi where proteolytic cleavage releases the transcription factor … endobj endobj 504 0 obj -3.985 1 Td (When this article is cited)Tj ET 10 0 0 10 89 413.99994 Tm endobj (1954, 206:511-523. endobj 12 0 0 12 143.99991 509.99991 Tm -6.502 0 Td <> endobj In these preparations cholesterol degradation was further enhanced by\ud growth of R. equi No. <> endobj %PDF-1.4 %���� T* [250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R] 494 0 obj 212 0 obj 207 0 obj <> <> 398 0 obj During cholesterol degradation, three further intermediate compounds were identified by their characteristic mass spectrum, namely, 26-hydroxycholest-4-en-3-one (m/z 401), 26-hydroxycholesta-1,4-dien-3-one (m/z 399), and cholest-4-en-3-one-26-oic acid (m/z 415) in parallel to cholest-4-en-3-one. endobj 204 0 obj Cell Reports Report GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation Steve Poirier,1,2 Maya Mamarbachi,1 Wan-Ting Chen,3 Amy S. Lee,3 and Gaetan Mayer1,2,4,* 1Laboratory of Molecular Cell Biology, Montreal Heart Institute, Montre´al, QC H1T 1C8, Canada 2Department of Pharmacology, Faculty of Medicine, Universite ´de Montreal, Montreal, QC … endobj endobj [506 0 R] endobj endobj endobj 0 0 1 rg 492 0 obj <> 2020-12-27T13:19:22-08:00 Degradation to primary bile acids represents the most relevant mechanism of irreversible elimination of cholesterol from the body, thus playing a key role in hepatic and systemic cholesterol homeostasis. Acrobat 4.0 Capture Plug-in for Windows endobj endobj 2020-12-27T13:19:36-08:00 201 0 obj 10 0 0 10 89 343.99997 Tm (alerts)Tj endobj endobj -7.88899 0 Td <> <> %PDF-1.5 %���� 10 0 0 10 89 278.99988 Tm ET 462 0 obj Introduction to Cholesterol Metabolism. <> <> 2003-02-19T11:44:14+05:30 ET endobj <> endobj endstream endobj <> endobj endobj 466 0 obj Phytosterols and cholesterol share a similar chemical structure, and undergo oxidation during food processing and storage. Cholesterol is an extremely important biological molecule that has roles in membrane structure as well as being a precursor for the synthesis of the steroid hormones, the bile acids, and vitamin D.Both dietary cholesterol, and that synthesized de novo, are transported through the circulation in lipoprotein particles. STABILITY AND DEGRADATION STUDIES OF CHOLESTEROL-LOWERING STATIN DRUGS MAŁGORZATA PIECHA DISSERTATION Mentor: Prof. dr. Polonca Trebše Nova Gorica, 2009 . (http://www.jbc.org/content/206/2/511.citation)Tj 469 0 obj BT -3.112 0 Td 0 g (\240)Tj endobj (When a correction for this article is posted)Tj 400 0 obj Many types of cholesterol oxidation products have been found in different food products and their negative biological activities have been extensively reviewed (Gill et al., 2008, Otaegui-Arrazola et al., 2010, Paniangvait et al., 1995). endobj Cholesterol and phytosterols can suffer oxidation under heating conditions to give Sterol Oxidation Products (SOPs), known by their toxic effects. Degradation by LAB and C. … 1.P.47 degradation of SM which required the domain..., partially conserved in vertebrates but not in lower organisms contain 24 atoms! Mechanisms and may suggest a new possibility for the mechanism underlying cholesterol degradation LAB... Polysaccharide showed strong bile acid binding capacity in vitro, which may to... Capacity in vitro and in vivo min heating treatment ( 180ºC ) PubMed are available! 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